Gene search result

Gene info

Gene Symbol: Klhl4 Gene in Aging Signature (AS)
Gene Description:
Ensembl ID: ENSMUSG00000025597
Chromosome: X
Organism: mouse

Gene found in signature
First author Organism Tissue Year Platform Title Pubmed ID
First author Organism Tissue Year Platform Title Pubmed ID
Renders mouse HSC 2021 bulk Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1. 33504783
Norddahl mouse HSC 2011 microarray Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging. 21549326
Bersenev mouse HSC 2012 microarray Lnk deficiency partially mitigates hematopoietic stem cell aging. 22812478
Wahlestedt mouse HSC 2013 microarray An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state. 23476050
Sun mouse HSC 2014 bulk Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. 24792119
Flach mouse HSC 2014 microarray Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells. 25079315
Grover mouse HSC 2016 sc Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells. 27009448
Maryanovich mouse HSC 2019 bulk Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche. 29736022