Gene search result

Gene info

Gene Symbol: Plek Gene in Aging Signature (AS)
Gene Description: pleckstrin
Ensembl ID: ENSMUSG00000020120
Chromosome: 11
Organism: mouse

Gene found in signature
First author Organism Tissue Year Platform Title Pubmed ID
First author Organism Tissue Year Platform Title Pubmed ID
Chambers mouse HSC 2007 microarray Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. 17676974
Norddahl mouse HSC 2011 microarray Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging. 21549326
Bersenev mouse HSC 2012 microarray Lnk deficiency partially mitigates hematopoietic stem cell aging. 22812478
Sun mouse HSC 2014 bulk Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. 24792119
Kowalczyk mouse HSC 2015 sc Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells. 26430063
Grover mouse HSC 2016 sc Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells. 27009448
Maryanovich mouse HSC 2019 bulk Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche. 29736022